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Given its essential role in the detoxification of lipid hydroperoxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to specifically trigger ferroptosis and eradicate myeloid leukemia cells
doi: 10.1016/j.celrep.2021.109886 54 DongZ.LvW.ZhangC.ChenS
Stop and reassess Stop the protocol and seek qualified medical care if pronounced symptoms appear: significant swelling, ongoing dizziness, rapid heart rate, shortness of breath, or marked fatigue
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Mechanistically, HOTAIR alleviates foam cell formation by inhibiting the expression of miR-19a-3p
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